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The purpose of this work is to outline the first steps taken towards the building of an automatic interpretation and hypothesis generation machine. The contents of this thesis describe the framework built to parse and manipulate the knowl- edge assemblies encoded in BEL, which enables BEL to act as a semantic inte- gration layer for heterogeneous data and knowledge sources, the development of a framework for automatic integration of relevant knowledge from structured sources, and the development of schema-free analytical techniques to generate data-driven hypothesis.

Plasticity models for thermo-mechanical appications

Simple resume for new grads.

#9774 Nano Ninjas is a rookie FTC Team consisting of fifteen girls in seventh and eighth grade and is a neighborhood team located in Portland, OR. This is our Engineering Notebook capturing every moment of of FTC journey. Read more about our amazing project in our story on the Overleaf blog. This is a big, detailed report at 300+ pages, so give it a few seconds to load! :-)

A two-day seminar on natural language processing applications and techniques, to undergraduates (diploma and bachelor programmes) at KDU College Penang, in March 2015.

Il s'agit des transparents d'une initiation à LaTeX, formation destinée aux doctorants de l'École doctorale SICMA. Elle est proposée chaque année à Télécom Bretagne (sur les sites de Brest ou de Rennes). À l'origine elle provient d'un cours que j'ai monté dans les années '90 pour l'association GUTenberg, et que j'ai donné des dizaines de fois en France et en Belgique, ces 20 dernières années. Les transparents ont bien évolué au gré des évolutions du monde TeX. Je me sers de ces transparents également pour un cours proposé aux professeurs de CPGE dans le cadre du groupe LIESSE. ATTENTION : il ne s'agit que de *transparents* de cours, ils ne sont ni exhaustifs ni suffisamment commentés pour servir à un véritable auto-apprentissage.

Odilia Almeida's CV

NIJE GOTOVO

Bacterial cells can have DNA damage due to transcriptional error, or through the effect of an antibiotic. The SOS response is a bacterial cell program for coping with DNA damage, in which the cell cycle is arrested, and DNA repair is induced. The repairs have high probability in leading to mutagenesis in the bacteria, which can lead to antibiotic resistance. The RecA protein in bacteria is responsible for the activation of the SOS response; therefore, making it a target for inhibition. I elected to use the ubiquitination system, natively used for apoptosis, as a means of targeted degradation of the RecA protein in bacteria prone to mutations. Polyubiquitination of misfolded proteins leads to the breaking down of the protein with the aid of proteasomes, which break down unnecessary proteins through a chemical reaction known as proteolysis. Using random forest-predictors, I determined a statistically high likelihood of ubiquitination of the RecA protein in MRSA, Tuberculosis, and other high risk bacterial infections. I hypothesized that I could foster ubiquitin-tagging on RecA by forcing the protein to misfold. Chaperones are proteins which interact with each other to prevent specific sets of proteins from misfolding. CHIP (C terminus of HSC70-Interacting Protein) is a biomolecule that inhibits interactions between the chaperones of RecA. Adding CHIP, ubiquitin, and 26s proteasomes into the bacterial system, should theoretically lead to the degradation of the RecA protein inside the bacteria. I tested my hypothesis by conducting an assay for monitoring CHIP-mediated ubiquitination, and conducted analysis on the assay using SDS- Page gel electrophoresis, and Western-blotting. The resulting data showed signs of polyubiquitination on the RecA protein, with chains of five or more ubiquitin, showing high drug potential. Adding an antibody drug conjugate, containing all the necessary components of a CHIP-mediated ubiquitination reaction, to common antibiotics can lead to the inhibition of bacterial mutagenesis, and higher antibiotic drug potency.