Articles — University

The aim of this thesis is to investigate the ability of cardiovascular biomarkers calculated from peripheral pulse waveforms to estimate central properties of the cardiovascular system (e.g. aortic stiffness) using nonlinear one-dimensional (1-D) modelling of pulse wave propagation in the arterial network. To test these biomarkers, I have produced novel 1-D models of pulse wave propagation under normal and pathological conditions. In the first part of my thesis, I extended the modelling capabilities of the existing 1-D/0-D code to represent arterial blood flow under diabetes, hypertension, and combined diabetes and hypertension. Cardiac and vascular parameters of the 1-D model were tailored to best match data available in the literature to produce generalised hypertensive, diabetic, and combined diabetic and hypertensive population models. Using these models, I have shown that the pulse waveform at the finger is strongly affected by the aortic flow wave and the muscular artery stiffness and diameter. Furthermore the peak to peak time measured from the pulse waveform at the finger can identify hypertensive from diabetic patients. In the second part, I developed a new methodology for optimising the number of arterial segments in 1-D modelling required to simulate precisely the blood pressure and flow waveforms at an arbitrary arterial location. This is achieved by systematically lumping peripheral 1-D model branches into 0-D models that preserve the net resistance and total compliance of the original model. The methodology is important to simplify the computational domain while maintaining the precision of the numerical predictions — an important step to translate 1-D modelling to the clinic. This thesis provides novel computational tools of blood flow modelling and waveform analysis for the design, development and testing of pulse wave biomarkers. These tools may help bridge the gap between clinical and computational approaches.

Proposta Projeto Integrador

Contains the thesis template using memoir class, which is mainly based on book class but permits better control of chapter styles for example. This template is an adaptation and modification of Oscar's. Memoir is a flexible class for typesetting poetry, fiction, non-fiction and mathematical works as books, reports, articles or manuscripts. UoB guidelines: The dissertation must be printed on A4 white paper. Paper up to A3 may be used for maps, plans, diagrams and illustrative material. Pages (apart from the preliminary pages) should normally be double-sided. Memoir class loads useful packages by default (see manual).

This simulation plan aims to explain and document all steps to be taken in the simulation analysis of the Fokker-100 case. This case is the scenario in which the aircraft touches the ground during landing, introducing loads on the landing gear. The landing gear consists of 2 rear gears around mid-span and one in the front. Furthermore, the pilot uses the rudder which induces a lateral force on the tail. As stated in the assignment, it is required to find the maximum normal stress and location of this in the fuselage, the maximum shear stress and its location in the fuselage, and the maximum shear flow in the frames that introduce the loads from the landing gears into the fuselage.

Chapters 1-3 of my PhD dissertation.

Considering the growing impact of ideas nowadays, via quaternary sector, the plagiarism detection has become constant in texts, songs, as well as source codes. This work proposes the creation of the tool \nameOfProgram \ for plagiarism detection in simple texts with GNU GPL license. \nameOfProgram \ was designed to allow your extension for plagiarism detection in source codes. The tool was tested and results are presented in this paper.

A dissertation submitted to the Southeast University on Mad Dash Car Crash 3D Car Racing Video Games.

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Em um estudo conduzido por pesquisadores da Fundação Pró-Sangue, em São Paulo, tem-se interesse em avaliar o tempo até a ocorrência de anemia em doadores de repetição. No entanto, profissionais da área médica reconhecem a existência de um grupo de doadores não suscetíveis à anemia por doações, os superdoadores. A ocorrência da anemia é definida com base em avaliações periódicas do hematócrito anterior às doações, caracterizando assim a censura intervalar do evento de interesse. São considerados para análise dois modelos semiparamétricos que contemplam tal estrutura de censura e a existência de uma proporção de indivíduos não suscetíveis. O primeiro modelo, proposto por \citeasnoun{Shen}, trata-se de um modelo de tempo de promoção com estimação baseada em uma variação do algoritmo EM para dados com censura intervalar.\citeasnoun{Lam} consideram um modelo de fragilidade com distribuição contínua positiva e massa no ponto zero para contemplar indivíduos não suscetíveis, caracterizando também a heterogeneidade das condições de saúde dos pacientes suscetíveis. Os modelos foram aplicados em dados que abrangem doações realizadas entre janeiro de 2003 e dezembro de 2006.